Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC018
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-06-27 09:44
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 25 individuals with a value less than 0.6 were subsequently diagnosed with PD. That is, 59.52% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.6 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 1, 'TP': 41, 'FP': 29}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 22, 'TN': 17, 'TP': 20, 'FP': 13}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 21, 'TN': 10, 'TP': 21, 'FP': 20}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 15, 'TP': 22, 'FP': 15}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 11.268
timePerCircleCoV 0.078134
timePerCircleSlope -0.0148234
meanError 1.46734
tremorFreq 4.39453
tremorRelPower 15.8028
tremorGyroAmpMean 0.0207113
tremorGyroAmpSlope -0.00397771
tremorGyroAmpCoV 0.341991
tremorCoordAmpMean 0.0476812
tremorCoordAmpSlope -0.00167499
tremorCoordAmpCoV 0.261583
tremorAccAmpMean 0.0593008
tremorAccAmpSlope -0.000637437
tremorAccAmpCoV 0.192546
tremorPcRelVar 0.718278
tremorPcX 0.709031
tremorPcY 0.705177

Circle Segment 1

Duration 13.48 s, Accuracy Estimate 1.716 (lower is better)

Circle Segment 2

Duration 11.72 s, Accuracy Estimate 1.605 (lower is better)

Circle Segment 3

Duration 10.96 s, Accuracy Estimate 1.456 (lower is better)

Circle Segment 4

Duration 10.32 s, Accuracy Estimate 1.441 (lower is better)

Circle Segment 5

Duration 11.6 s, Accuracy Estimate 1.258 (lower is better)

Circle Segment 6

Duration 10.76 s, Accuracy Estimate 1.242 (lower is better)

Circle Segment 7

Duration 10.96 s, Accuracy Estimate 1.293 (lower is better)

Circle Segment 8

Duration 11.24 s, Accuracy Estimate 1.231 (lower is better)

Circle Segment 9

Duration 10.72 s, Accuracy Estimate 1.189 (lower is better)

Circle Segment 10

Duration 10.92 s, Accuracy Estimate 2.241 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 22.276
timePerSpiralCoV 0.168729
timePerSpiralSlope -0.0229082
meanError 1.74086
tremorFreq 7.12891
tremorRelPower 26.841
tremorGyroAmpMean 0.016817
tremorGyroAmpSlope 0.00094156
tremorGyroAmpCoV 0.398209
tremorCoordAmpMean 0.0442133
tremorCoordAmpSlope 0.000466624
tremorCoordAmpCoV 0.282853
tremorAccAmpMean 0.0317128
tremorAccAmpSlope 0.000762898
tremorAccAmpCoV 0.356132
tremorPcRelVar 0.748323
tremorPcX 0.765036
tremorPcY 0.643987

Spiral Segment 1

Duration 32.44 s, Accuracy Estimate 1.726 (lower is better)

Spiral Segment 2

Duration 18.52 s, Accuracy Estimate 1.644 (lower is better)

Spiral Segment 3

Duration 22.52 s, Accuracy Estimate 1.861 (lower is better)

Spiral Segment 4

Duration 20.76 s, Accuracy Estimate 1.761 (lower is better)

Spiral Segment 5

Duration 21.08 s, Accuracy Estimate 1.839 (lower is better)

Spiral Segment 6

Duration 22.56 s, Accuracy Estimate 1.703 (lower is better)

Spiral Segment 7

Duration 21.56 s, Accuracy Estimate 1.676 (lower is better)

Spiral Segment 8

Duration 20.2 s, Accuracy Estimate 1.795 (lower is better)

Spiral Segment 9

Duration 21.48 s, Accuracy Estimate 1.698 (lower is better)

Spiral Segment 10

Duration 21.64 s, Accuracy Estimate 1.705 (lower is better)

Elel

eDurationMean 0.400429
eDurationStd 0.166731
eDurationStdnorm 0.41638
eDurationMedian 0.345
eDurationQuartdelta 0.08875
eDurationQuartdeltanorm 0.257246
eDurationKurt 21.5129
eDurationTrenddiff -0.05
eDurationTrendratio 0.87013
eWidthMean 5.01094
eWidthStd 1.31408
eWidthStdnorm 0.262243
eWidthMedian 4.797
eWidthQuartdelta 1.8135
eWidthQuartdeltanorm 0.378049
eWidthKurt 2.61913
eWidthTrenddiff 0.819
eWidthTrendratio 1.18421
eHeightMean 11.4292
eHeightStd 1.31967
eHeightStdnorm 0.115465
eHeightMedian 11.7
eHeightQuartdelta 1.521
eHeightQuartdeltanorm 0.13
eHeightKurt 3.60985
eHeightTrenddiff 0.936
eHeightTrendratio 1.08696
eAspectMean 0.438436
eAspectStd 0.10473
eAspectStdnorm 0.238872
eAspectMedian 0.419355
eAspectQuartdelta 0.151209
eAspectQuartdeltanorm 0.360576
eAspectKurt 2.05806
eAspectTrenddiff 0.0602486
eAspectTrendratio 1.15514
eSlantMean -0.012459
eSlantStd 0.149087
eSlantStdnorm -11.9662
eSlantMedian -0.0454545
eSlantQuartdelta 0.179424
eSlantQuartdeltanorm -3.94733
eSlantKurt 3.97098
eSlantTrenddiff 0.0278245
eRtopMean 0.779645
eRtopStd 0.0914149
eRtopStdnorm 0.117252
eRtopMedian 0.8
eRtopQuartdelta 0.125696
eRtopQuartdeltanorm 0.15712
eRtopKurt 2.42839
eRtopTrenddiff 0.0230263
eRbotMean 0.856118
eRbotStd 0.257228
eRbotStdnorm 0.300458
eRbotMedian 0.870968
eRbotQuartdelta 0.267521
eRbotQuartdeltanorm 0.307153
eRbotKurt 3.74049
eRbotTrenddiff -0.150463
eRrightMean 0.872455
eRrightStd 0.0554251
eRrightStdnorm 0.0635277
eRrightMedian 0.879518
eRrightQuartdelta 0.0726892
eRrightQuartdeltanorm 0.0826466
eRrightKurt 3.38285
eRrightTrenddiff 0.0318857
eRleftMean 0.408028
eRleftStd 0.0894552
eRleftStdnorm 0.219238
eRleftMedian 0.42
eRleftQuartdelta 0.122517
eRleftQuartdeltanorm 0.291706
eRleftKurt 2.37464
eRleftTrenddiff -0.0356962
lDurationMean 0.5325
lDurationStd 0.12844
lDurationStdnorm 0.241201
lDurationMedian 0.51
lDurationQuartdelta 0.0975
lDurationQuartdeltanorm 0.191176
lDurationKurt 9.16332
lDurationTrenddiff -0.0975
lDurationTrendratio 0.823529
lWidthMean 9.93038
lWidthStd 1.82318
lWidthStdnorm 0.183597
lWidthMedian 10.413
lWidthQuartdelta 2.808
lWidthQuartdeltanorm 0.269663
lWidthKurt 3.02623
lWidthTrenddiff 2.2815
lWidthTrendratio 1.26174
lHeightMean 29.9739
lHeightStd 2.50751
lHeightStdnorm 0.0836564
lHeightMedian 30.2445
lHeightQuartdelta 4.0365
lHeightQuartdeltanorm 0.133462
lHeightKurt 2.55018
lHeightTrenddiff -3.861
lHeightTrendratio 0.879562
lAspectMean 0.333918
lAspectStd 0.0668943
lAspectStdnorm 0.200331
lAspectMedian 0.35119
lAspectQuartdelta 0.0976062
lAspectQuartdeltanorm 0.27793
lAspectKurt 2.96412
lAspectTrenddiff 0.0725293
lAspectTrendratio 1.23902
lSlantMean 0.086716
lSlantStd 0.0605278
lSlantStdnorm 0.697999
lSlantMedian 0.0837612
lSlantQuartdelta 0.0931308
lSlantQuartdeltanorm 1.11186
lSlantKurt 2.04899
lSlantTrenddiff 0.0117157
lRtopMean 0.882638
lRtopStd 0.055723
lRtopStdnorm 0.0631324
lRtopMedian 0.883518
lRtopQuartdelta 0.0817092
lRtopQuartdeltanorm 0.0924816
lRtopKurt 2.83693
lRtopTrenddiff -0.0043275
lRbotMean 0.643451
lRbotStd 0.12946
lRbotStdnorm 0.201197
lRbotMedian 0.619792
lRbotQuartdelta 0.211496
lRbotQuartdeltanorm 0.341238
lRbotKurt 2.62432
lRbotTrenddiff 0.0145723
lRrightMean 0.930679
lRrightStd 0.0363684
lRrightStdnorm 0.0390773
lRrightMedian 0.935669
lRrightQuartdelta 0.0521472
lRrightQuartdeltanorm 0.0557325
lRrightKurt 3.3234
lRrightTrenddiff 0.0245439
lRleftMean 0.282719
lRleftStd 0.0809251
lRleftStdnorm 0.286239
lRleftMedian 0.286103
lRleftQuartdelta 0.0808409
lRleftQuartdeltanorm 0.282558
lRleftKurt 8.09413
lRleftTrenddiff 0.0445857

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

FITTS Short Modified

meanTouchScore 0.955144
sumTouchScores 27.6992
meanMovementTime 0.664286
numTouches 29
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.916335
sumTouchScores 18.3267
meanMovementTime 0.868947
numTouches 20
undershootPercentage 5
overshootPercentage 20

ZigZag

numZigzags 5
timePerZigzagMean 24.528
timePerZigzagCoV 0.125133
timePerZigzagSlope 0.0526745
meanError 1.7426
tremorFreq 6.25
tremorRelPower 22.3156
tremorGyroAmpMean 0.0197905
tremorGyroAmpSlope -0.001227
tremorGyroAmpCoV 0.343701
tremorCoordAmpMean 0.0472783
tremorCoordAmpSlope -0.000370916
tremorCoordAmpCoV 0.289151
tremorAccAmpMean 0.0811037
tremorAccAmpSlope 0.000130673
tremorAccAmpCoV 0.0920095
tremorPcRelVar 0.696187
tremorPcX -0.596794
tremorPcY -0.802394

ZigZag Segment 1

Duration 21.04 s, Accuracy Estimate 1.765 (lower is better)

ZigZag Segment 2

Duration 22.24 s, Accuracy Estimate 1.647 (lower is better)

ZigZag Segment 3

Duration 26.44 s, Accuracy Estimate 1.797 (lower is better)

ZigZag Segment 4

Duration 28.6 s, Accuracy Estimate 1.687 (lower is better)

ZigZag Segment 5

Duration 24.32 s, Accuracy Estimate 1.817 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 10.12
timePerZigzagCoV 0.193131
timePerZigzagSlope -0.111858
zigzagHeightMean 80.9271
zigzagHeightCoV 0.021949
zigzagHeightSlope 0.00963864
meanError 0.0364903
tremorFreq 6.64062
tremorRelPower 24.7318
tremorGyroAmpMean 0.0399081
tremorGyroAmpSlope 0.00505592
tremorGyroAmpCoV 0.297249
tremorCoordAmpMean 0.105487
tremorCoordAmpSlope 0.00181547
tremorCoordAmpCoV 0.223486
tremorAccAmpMean 0.0802085
tremorAccAmpSlope 0.00504973
tremorAccAmpCoV 0.248258
tremorPcRelVar 0.702242
tremorPcX -0.473688
tremorPcY -0.880693

ZigZag Offset Segment 1

Duration 12.52 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 2

Duration 11.96 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 3

Duration 8.84 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 4

Duration 8.88 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 5

Duration 8.4 s, Accuracy Estimate 0.048 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.74}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.6}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.8330874179520651}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Healthy’, ‘BM_HC_Sep22_score’: 0.31414977994129467}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7740070014563843}